By F.J. Dixon, Henry G. Kunkel (Eds.)
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Extra resources for Advances in Immunology, Vol. 20
Those unique antigenic determinants (idiotypic) that mark the individuality of particular immunoglobulin molecules reflect properties of some or all of the hypervariable regions. The nature and extent of the correlation of idiotypic properties with specific antibody activities or particular subgroups is not yet clear. The inheritance of idiotypy is now clearly established in the rabbit and the mouse. This phenomenon has profound implications for any hypothesis purporting to explain the origin of antibody diversity, and, although alternative explanations are possible, it is one of the strongest current arguments supporting a pure germ-line theory.
And Krause, R. M. (1973b). J. E x p . Med. 138, 522. , and Putnam, F. W. (1970). Nature (London) 227, 1318. Koo, P. , and Cebra, J. J. (1974). Biochemistry 13, 184. Kuettner, M. , Wang, A. , and Nisonoff, A. (1972). J. E x p . Med. 135, 579. Kunkel, H. , and Williams, R. C. (1963). Science 140, 1218. VARIABLE REGIONS, IDIOTYPY, AM) COMBINING SITE 39 Kunkel, H. , Joslin, F. , Winchester, R. , and Capra, J. D. (1973). J. Erp. Med. 137, 311. Kunkel, H. , Winchester, R. , Joslin, F. , and Capra, J.
Heavy-chain positions 8491, which form a hypervariable region, were not found in the groove, nor in contact with lightchain residues, although they do occur on the outside of the molecule. This study provides the best evidence to date for the participation of the hypervariable regions in the antibody-combining site. These fundamental findings will be advanced even further when crystallographic analyses permit the observation of a binding site with a hapten actually in place, to confirm the precise location and configuration of the site.