Advances in Genetics by M. Demerec (Eds.)

By M. Demerec (Eds.)

This quantity in a sequence on genetics, emphasizes the variety of genetic reviews. Articles conceal the filamentous fungus neurospora, biogenesis of yeast ribosomes, evolutionary genetics of fish, drosophila transposable components and the dropophila gene zeste.

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6. Isoleucine and Valine ................. Choline ........................ 8. pAminobenzoic Acid and Sulfanilamide . . . . . . Thiamine ....................... 10. Riboflavin ....................... 11 Pantothenic Acid . . . . . . . . . . . 12. Succinic Acid . . . . . . . . . . . 13. Nucleic Acid Constituents . . . . . . . . a . Purines b . Pyrimidines . . . . . . . . . . . I V. The Gene as a Unit of Function . . . . . . . . 1. The One Gene-One Enzyme Hypothesis .

50 51 52 63 55 . ........................ . . 35 37 57 57 57 58 58 59 60 60 62 65 68 I . INTRODUCTION The theory of the gene. in its fundamental aspects. was essentially complete by 1915. We are still engaged in the elaboration of that theory . By establishing the idea that the hereditary determiners are material elements of the cell. the gene theory bridged the gap. in concept a t least. between the study of heredity on the one hand and biochemistry on the other . The first biochemical genetical investigation had already been carried out by Garrod (1909) in his famous study of human alcaptonuria.

B. macerans. 60-hour culture in aerated G R medium a t 30°C. Giemsa staining. 54. Top row: Various aspects of cells. Nuclear element, n. At left, normal young cells. At right, beginning of formation of spore by swelling; about onethird of the nuclear substance breaks off and becomes round, then ovoid to form the sporal nuclear corpuscle. Bottom row : Unusual arrangement of the nuclear substance, seen in the same culture. 55. Various aspects of almost-ripe spores, with nuclear element a t the periphery, and remains of nuclear substance at the poles of the spore.

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